The design of low and medium-rise buildings has, for some time, taken climatic variations and sustainability into account. However, despite the increase in the number of large-scale buildings worldwide during the last few decades, high-rise buildings are still seen as mega-scale energy consumers with little regard for sustainable design and performance. The current environmental agenda and interest in sustainability across the globe raises the significance of mega-buildings. On this interdisciplinary course, we focus on the principles of sustainable planning and design of mega-buildings and prepare students to specialise professionally in this field.